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KMID : 1195620160090030192
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Clinical and Experimental Otorhinolaryngology
2016 Volume.9 No. 3 p.192 ~ p.197
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Efficacy of Trimetazidine Dihydrochloride for Relieving Chronic Tinnitus: A Randomized Double-Blind Study
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Tolgar Lutfi Kumral
Guven Yıldırım
Guler Berkiten
Ziya Salturk
Enes Atac
Yavuz Atar
Yavuz Uyar
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Abstract
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Objectives:To evaluate the efficacy of trimetazidine dihydrochloride as a treatment for chronic tinnitus.
Methods:A total of 97 chronic tinnitus patients were evaluated in this randomized, prospective, double-blind, placebo-controlled trial. After assessing for eligibility, 82 patients were randomly assigned into placebo or trimetazidine groups according to the medication. The trimetazidine group received 20×3 mg/day per oral trimetazidine dihydrochloride and the placebo group received 20×3 mg/day per oral placebo for 3 months. Tinnitus handicap inventory (THI), visual analogue scale (VAS) questionnaires and audiometric results were used to determine the effectiveness of trimetazidine treatment.
Results:The study group comprised 82 tinnitus subjects, 42 (51%) of whom received trimetazidine dihydrochloride and 40 (49%) who received placebo. There was no significant difference between placebo and trimetazidine groups in THI grade and VAS (both pre- and posttreatment scores) (P>0.05) and no significant improvement was observed in subjective loudness score in either group (P>0.05). Additionally there was no significant difference between groups in pre- and posttreatment pure tone hearing thresholds at all measured frequencies (P>0.05).
Conclusion:Trimetazidine dihydrochloride therapy was ineffective for relieving chronic tinnitus.
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KEYWORD
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Tinnitus, Trimetazidine dihydrochloride, Drug treatment
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